Novel Biomarkers

Novel Possible Biomarkers for the Cardiovascular Diseases Prognosis

Cardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide. Furthermore, oxidative and inflammatory processes represent fundamental underlying mechanisms for the development and progression of HF. Of interest, in recent years the development of markers with diagnostic and prognostic value for this pathology ...

Biomarkers: Its Novel Application

Submitted 2011.08.28. Accepted for publication 2011.12.13. Advances in biotechnology and improved understanding of cancer and disease biology have shifted the treatment paradigm to targeted therapy. We have enhanced our ability to guide application of new and existing treatments with development, assay verification, biological validation and application of biomarkers. However, to be successful,...

MicroRNAs as novel myocardial biomarkers.

The search for new biomarkers of cardiovascular disease remains a large and growing enterprise. Biomarkers are used to identify the risk, presence, and/or severity of disease; to guide diagnostic and therapeutic interventions; and to provide clues to disease mechanisms and pathophysiological distinctions within clinically similar populations. Among cardiovascular biomarkers, those used for iden...

Novel Biomarkers in Pancreatic Cancer

Identification of novel brain biomarkers.

BACKGROUND The diagnosis of diseases leading to brain injury, such as stroke, Alzheimer disease, and Parkinson disease, can often be problematic. In this study, we pursued the discovery of biomarkers that might be specific and sensitive to brain injury. METHODS We performed gene array analyses on a mouse model to look for biomarkers that are both preferentially and abundantly produced in the ...